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Newer therapies are emerging and currently under study for the management of HE targeting traditional mechanisms of ammonia clearance in addition to novel mechanisms related to altering gut microbiome, reducing inflammation and oxidative stress, protecting endothelial integrity, and modifying neuronal responses (Fig
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However, in erythrocytes, GSH levels after SAG administration were slightly lower than those observed with the GSH product, suggesting a complex regulation of GSH and its oxidized form (GSSG) within erythrocytes
Administration route significantly impacts optimal dosing frequency
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